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The BCDD Infrastructure

The BCDD Infrastructure
Computer-Assisted Drug Design Unit at the BLAVATNIK CENTER for Drug Discovery

Computer-Assisted Drug Design Unit

The BCDD combines computational aspects in the drug discovery process, in particular, target-structure modeling, molecular docking and structure based drug design. For these purposes, the BCDD uses both commercially available and TAU-developed highly efficient software tools.

 

HTS Biological Assays Unit

The research capabilities of the High Throughput Screening (HTS) and Biological Assays Unit at the BCDD include:

Cell culture of multiple cell types modeling disease.

Performance of a diverse range of biological assays adapted for HTS of drugs in 96, 384 or 1536 well plates such as:

  • Image-based HTS analysis assays
  • HT QRT-PCR and miRNA microarray assays
  • HT fluorometry – spectrometry – luminometry assays 
  • HT DNA-RNA-Protein extraction for "omics"

 

BCDD Org Chart

 

Medicinal Chemistry Unit

The Medicinal Chemistry Unit at the BCDD provides a continuous process from hit prioritization and analysis, through in-house synthesis, analogue design, structure-activity relationship studies and final optimization. The Unit is equipped with ultra modern synthetic and analytical equipment in order to accelerate the "hit to lead" optimization process. Founded on the principle of scientific innovation, the BCDD is focused on sustaining capabilities for cutting-edge formulation and drug delivery technologies for solubility and bioavailability enhancement.

Tel Aviv University, P.O. Box 39040, Tel Aviv 6997801, Israel
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