Postdoctoral Fellow at the BCDD HTS Unit
E-mail: ohadmeir@tauex.tau.ac.il
Dr. Ohad Meir graduated from the Faculty of Biotechnology and Food Engineering at the Technion - Israel Institute of Technology, where he was mentored by Prof. Amram Mor, with whom he studied de-novo design and development of antimicrobial peptide mimics. He completed his M.Sc. summa cum laude in 2017, and his Ph.D. in 2022. During that period, he mastered techniques pertaining to peptide chemistry (design, synthesis, LC-MS, light scattering), as well as to their assessment in-vitro (microdilution assay and checkerboard titrations, growth kinetics, selective pressure, membrane integrity analyses and biofilm studies) and in-vivo using various murine models (acute toxicity, pharmacokinetics and biodistribution, peritonitis sepsis, thigh infection, UTI as well as skin-wound infection).
In his publications, he contributed to establish the notion that non-antibiotic lipopeptide-like agents can generate superficial and transient membrane damages that can nevertheless be harnessed for substantial potentiation of ineffective antimicrobials.
Dr. Meir joined the BCDD’s HTS unit as a research fellow in 2023, where he leads various high throughput screening projects from the assay development stages through their successive execution towards identification of new drug candidates. These are accomplished through utilization of cellular- as well as enzymatic-based platforms, respectively assessing phenotypic and mechanistic effects of tested compound libraries.
List of publications:
Meir, O., Zaknoon, F., Mor, A.; An Efflux-Susceptible Antibiotic-Adjuvant with Systemic Efficacy Against Mouse Infections. 2022, Sci. Rep.
Zaknoon, F., Meir, O., Mor A.; Mechanistic Studies of Antibiotic Adjuvants Reducing Kidney’s Bacterial Loads upon Systemic Monotherapy. 2021, Pharmaceutics.
Hershkovits, A.S., Pozdnyakov, I., Meir, O., Mor, A.; Sub-Inhibitory Membrane Damage Undermines Staphylococcus aureus virulence. 2019, BBA – Biomembranes.
Meir, O., Zaknoon, F., Cogan, U., Mor, A.; A Broad-Spectrum Bactericidal Lipopeptide with Anti-Biofilm Properties. 2017, Sci. Rep.
Kaneti, G., Meir, O., Mor, A.; Controlling Bacterial Infections by Inhibiting Proton-Dependent Processes. 2016, BBA – Biomembranes.
Marjieh, I., Meir, O., Zaknoon, F., Mor, A.; Improved Bacterial Detection using Immobilized Acyl-Lysyl Oligomers. 2015, AEM.
Zaknoon, F., Wein, S., Krugliak, M., Meir, O., Rotem, S., Ginsburg, H., Vial, H., Mor, A.; Antiplasmodial Properties of Acyl-Lysyl Oligomers in Culture and Animal Models of Malaria. 2011, AAC.
