Scientific Publications

Optimization Strategies for Mass Spectrometry-Based Untargeted Metabolomics Analysis of Small Polar Molecules in Human Plasma
Optimization Strategies for Mass Spectrometry-Based Untargeted Metabolomics Analysis of Small Polar Molecules in Human Plasma

Michał Kaczmarek, Nanyun Zhang, Ludmila Buzhansky, Sharon Gilead and Ehud Gazit

Tumor Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Human Breast Cancer Are Mediated by PD-L1-S283 and Chemokine Axes
Tumor Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Human Breast Cancer Are Mediated by PD-L1-S283 and Chemokine Axes

Nofar Erlichman, Tamir Baram, Tsipi Meshel, Dina Morein, Benny Da'adoosh, Adit Ben-Baruch 

 

The antipsychotropic drug Duloxetine rescues PAX6 haploinsufficiency of mutant limbal stem cells through inhibition of the MEK/ERK signaling pathway
The antipsychotropic drug Duloxetine rescues PAX6 haploinsufficiency of mutant limbal stem cells through inhibition of the MEK/ERK signaling pathway

Orly Dorot, Lauriane N. Roux, L´ea Zennaro, Keren Oved, Dominique Bremond-Gignac, Edward Pichinuk, Daniel Aberdam Download PDF Version>>

Ritanserin, a potent serotonin 2A receptor antagonist, represses MEK/ERK signalling pathway to restore PAX6 production and function in aniridia-like cellular model
Ritanserin, a potent serotonin 2A receptor antagonist, represses MEK/ERK signalling pathway to restore PAX6 production and function in aniridia-like cellular model

Keren Oved, Léa Zennaro, Orly Dorot, Johanna Zerbib, Elie Frank, Lauriane N.Roux, Dominique Bremond-Gignac, Edward Pichinuk, Daniel Aberdam

Chemical Chaperones Modulate the Formation of Metabolite Assemblies
Chemical Chaperones Modulate the Formation of Metabolite Assemblies

Hanaa Adsi, Shon A. Levkovich, Elvira Haimov, Topaz Kreiser, Massimiliano Meli, Hamutal Engel, Luba Simhaev, Shai Karidi-Heller, Giorgio Colombo, Ehud Gazit, Dana Laor Bar-Yosef

Self-Assembled Peptide Nano-Superstructure towards Enzyme Mimicking Hydrolysis
Self-Assembled Peptide Nano-Superstructure towards Enzyme Mimicking Hydrolysis

Dr. Yu Chen,Yuqin Yang,Asuka A. Orr,Dr. Pandeeswar Makam,Dr. Boris Redko,Dr. Elvira Haimov,Yannan Wang,Dr. Linda J. W. Shimon,Dr. Sigal Rencus-Lazar,Prof. Meiting Ju,Prof. Phanourios Tamamis,Prof. Hao Dong,Prof. Ehud Gazit

Alleviation of a polyglucosan storage disorder by enhancement of autophagic glycogen catabolism
Alleviation of a polyglucosan storage disorder by enhancement of autophagic glycogen catabolism

Or Kakhlon, Hilla Vaknin, Kumudesh Mishra, Jeevitha D'Souza, Monzer Marisat, Uri Sprecher, Shane Wald-Altman, Anna Dukhovny, Yuval Raviv, Benny Da'adoosh, Hamutal Engel, Sandrine Benhamron, Keren Nitzan, Sahar Sweetat, Anna Permyakova, Anat Mordechai, Hasan Orhan Akman, Hanna Rosenmann, Alexander Lossos, Joseph Tam, Berge A Minassian, Miguel Weil

A unique mechanism of inactivation gating of the Kv channel family member Kv7.1 and its modulation by PIP2 and calmodulin
A unique mechanism of inactivation gating of the Kv channel family member Kv7.1 and its modulation by PIP2 and calmodulin

Maya Lipinsky, William Sam Tobelaim, Asher Peretz, Luba Simhaev, Adva Yeheskel, Daniel Yakubovich, Guy Lebel, Yoav Paas, Joel A. Hirsch and Bernard Attali

TOR Complex 2 - independent mutations in the regulatory PIF pocket of Gad8 AKT1/SGK1 define separate branches of the stress response mechanisms in fission yeast
TOR Complex 2 - independent mutations in the regulatory PIF pocket of Gad8 AKT1/SGK1 define separate branches of the stress response mechanisms in fission yeast

Emese Pataki, Luba Simhaev, Hamutal Engel, Adiel Cohen, Martin Kupiec, Ronit Weisman 

Structural basis of heterotetrameric assembly and disease mutations in the human cis-prenyltransferase complex
Structural basis of heterotetrameric assembly and disease mutations in the human cis-prenyltransferase complex

Michal Lisnyansky Bar-El, Pavla Vaňková, Adva Yeheskel, Luba Simhaev, Hamutal Engel, Petr Man, Yoni Haitin & Moshe Giladi

Self-assembled peptide nano-superstructure towards enzyme mimicking hydrolysis
Self-assembled peptide nano-superstructure towards enzyme mimicking hydrolysis

Ehud Gazit,Yu Chen,Yuqin Yang, Asuka A. Orr, Pandeeswar Makam, Boris Redko, Elvira Haimov, Yannan Wang, Linda J. W. Shimon, Sigal Rencus-Lazar, Meiting Ju, Phanourios Tamamis, Hao Dong

Continuous Inflammatory Stimulation Leads via Metabolic Plasticity to a Prometastatic Phenotype in Triple-Negative Breast Cancer Cells
Continuous Inflammatory Stimulation Leads via Metabolic Plasticity to a Prometastatic Phenotype in Triple-Negative Breast Cancer Cells

Dina Morein, Linor Rubinstein-Achiasaf,,Hadar Brayer, Orly Dorot, Edward Pichinuk, Hagar Ben-Yaakov, Tsipi Meshel, Metsada Pasmanik-Chor and Adit Ben-Baruch
 

Persistent Inflammatory Stimulation Drives the Conversion of MSCs to Inflammatory CAFs That Promote Pro-Metastatic Characteristics in Breast Cancer Cells
Persistent Inflammatory Stimulation Drives the Conversion of MSCs to Inflammatory CAFs That Promote Pro-Metastatic Characteristics in Breast Cancer Cells

Linor Rubinstein-Achiasaf, Dina Morein, Hagar Ben-Yaakov, Yulia Liubomirski, Tsipi Meshel, Eti Elbaz, Orly Dorot, Edward Pichinuk, Michael Gershovits, Miguel Weil, Adit Ben-Baruch

p67phox‐derived self‐assembled peptides prevent Nox2 NADPH oxidase activation by an auto‐inhibitory mechanism
p67phox‐derived self‐assembled peptides prevent Nox2 NADPH oxidase activation by an auto‐inhibitory mechanism

Edna Bechor, Anat Zahavi, Yevgeny Berdichevsky, Edgar Pick

Inhibition of tau amyloid formation and disruption of its preformed fibrils by Naphthoquinone-Dopamine hybrid
Inhibition of tau amyloid formation and disruption of its preformed fibrils by Naphthoquinone-Dopamine hybrid

Ashim Paul, Guru KrishnaKumar Viswanathan, Adi Huber, Elad Arad, Hamutal Engel, Raz Jelinek, Ehud Gazit, Daniel Segal
 

Inhibition of amyloid fibrillation of γD-crystallin model peptide by the cochineal Carmine
Inhibition of amyloid fibrillation of γD-crystallin model peptide by the cochineal Carmine

MalakAbu-Hussien, Guru Krishnakumar Viswanathan, Lia Borisover, Michael Mimouni, Hamutal Engel, Shiri Zayit-Soudry, Ehud Gazit, Daniel Segal

In vivo anti‑MUC1+ tumor activity and sequences of high‑afnity anti‑MUC1‑SEA antibodies
In vivo anti‑MUC1+ tumor activity and sequences of high‑afnity anti‑MUC1‑SEA antibodies
Edward Pichinuk, Michael Chalik, Itai Benhar, Ravit Ginat‑Koton, Ravit Ziv, Nechama I. Smorodinsky, Gabi Haran, Christian Garbar, Armand Bensussan, Alan Meeker, Thierry Guillaume, Daniel B. Rubinstein, Daniel H. Wreschner
A novel specific PERK activator reduces toxicity and extends survival in Huntington's disease models
A novel specific PERK activator reduces toxicity and extends survival in Huntington's disease models

Javier Ganz, Talya Shacham,  Maria Kramer, Marina Shenkman, Hagit Eiger, Nitai Weinberg, Ori Iancovici, Somnath Roy, Luba Simhaev, Benny Da’adoosh, Hamutal Engel, Nisim Perets, Yael Barhum, Moshe Portnoy, Daniel Offen & Gerardo Z. Lederkremer

Chemical Modifications Reduce Auditory Cell Damage Induced by Aminoglycoside Antibiotics
Chemical Modifications Reduce Auditory Cell Damage Induced by Aminoglycoside Antibiotics

​Sivan Louzoun Zada, Bar Ben Baruch, Luba Simhaev, Hamutal Engel, and Micha Fridman

Treatment of hereditary hypotrichosis simplex of the scalp with topical gentamicin
Treatment of hereditary hypotrichosis simplex of the scalp with topical gentamicin

A. Peled  L. Samuelov  O. Sarig  R. Bochner  L. Malki  M. Pavlovsky  E. Pichinuk  M. Weil  E. Sprecher

Purpurin modulates Tau-derived VQIVYK fibrillization and ameliorates Alzheimer’s disease-like symptoms in animal model
Purpurin modulates Tau-derived VQIVYK fibrillization and ameliorates Alzheimer’s disease-like symptoms in animal model

Guru Krishnakumar Viswanathan, Dana Shwartz, Yelena Losev, Elad Arad, Chen Shemesh, Edward Pichinuk, Hamutal Engel, Avi Raveh, Raz Jelinek, Itzik Cooper, Fabien Gosselet, Ehud Gazit, Daniel Segal

 

Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles
Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles

Rebecca Elias, Raphael I. Benhamou, Qais Z. Jaber, Orly Dorot, Sivan Louzoun Zada, Keren Oved, Edward Pichinuk, Micha Fridman

Mechanisms of metabolite amyloid formation: computational studies for drug design against metabolic disorders
Mechanisms of metabolite amyloid formation: computational studies for drug design against metabolic disorders

Massimiliano Meli, Hamutal Engel, Dana Laor, Ehud Gazit and Giorgio Colombo 

Differential inhibition of metabolite amyloid formation by generic fibrillation-modifying polyphenols
Differential inhibition of metabolite amyloid formation by generic fibrillation-modifying polyphenols

Shira Shaham-Niv, Pavel Rehak, Dor Zaguri, Aviad Levin, Lihi Adler-Abramovich, Lela Vuković, Petr Král & Ehud Gazit 

Metabolite amyloid-like fibrils interact with model membranes

Shira Shaham-Niv, Pavel Rehak, Dor Zaguri, Sofiya Kolusheva, Petr Králbde and Ehud Gazit  

Antibodies towards tyrosine amyloid-like fibrils allow toxicity modulation and cellular imaging of the assemblies
Antibodies towards tyrosine amyloid-like fibrils allow toxicity modulation and cellular imaging of the assemblies

Dor Zaguri, Topaz Kreiser, Shira Shaham-Niv and Ehud Gazit

Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation
Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of...

Dana Laor, Dorin Sade, Shira Shaham-Niv, Dor Zaguri, Myra Gartner, Vasantha Basavalingappa, Avi Raveh, Edward Pichinuk, Hamutal Engel, Keita Iwasaki, Tatsuyuki Yamamoto, Hemanth Noothalapati & Ehud Gazit 

Tuning the molecular weight of polymeric amphiphiles as a tool to access micelles with a wide range of enzymatic degradation rates
Tuning the molecular weight of polymeric amphiphiles as a tool to access micelles with a wide range of enzymatic degradation rates

Gadi Slor, Nitsan Papo, Uri Hananel and Roey J. Amir

Real-time imaging of the azole class of antifungal drugs in live candida cells
Real-time imaging of the azole class of antifungal drugs in live candida cells

Raphael I. Benhamou, Maayan Bibi, Kfir B. Steinbuch, Hamutal Engel, Maayan Levin, Yael Roichman, Judith Berman and Micha Fridman

Modular synthetic approach for adjusting the disassembly rates of enzyme-responsive polymeric micelles
Modular synthetic approach for adjusting the disassembly rates of enzyme-responsive polymeric micelles

Assaf J. Harnoy, Marina Buzhor, Einat Tirosh, Rona Shaharabani, Roy Beck and Roey J. Amir

Reversible dimerization of polymeric amphiphiles acts as a molecular switch of enzymatic degradability
Reversible dimerization of polymeric amphiphiles acts as a molecular switch of enzymatic degradability

Ido Rosenbaum, Ram Avinery, Assaf J. Harnoy, Gadi Slor, Einat Tirosh, Uri Hananel, Roy Beck and Roey J. Amir

Micellar stability in biological media dictates internalization in living cells
Micellar stability in biological media dictates internalization in living cells

Natalia Feiner-Gracia, Marina Buzhor, Edgar Fuentes, Sílvia Pujals, Roey J. Amir and Lorenzo Albertazzi

Integrating in vitro and in silico approaches to evaluate the "dualfunctionality" of palmatine chloride in inhibiting and disassembling Tau-derived VQIVYK peptide fibrils
Integrating in vitro and in silico approaches to evaluate the "dualfunctionality" of palmatine chloride in inhibiting and disassembling Tau-derived VQIVYK peptide fibrils

Esraa Haj, Yelena Loseva, V. Guru Krishna Kumarad, Edward Pichinukc, Hamutal Engel, Avi Raveh, Ehud Gazit, Daniel Segal

 

 
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