Medicinal Chemistry Unit
The Medicinal Chemistry Unit provides a continuous process from hit prioritization to final optimization, equipped with ultra-modern synthetic and analytical equipment to accelerate the "hit to lead" optimization process.
Device |
Description |
Connect Manufacturer |
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Organic Synthesis |
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The Discover SP is a powerful microwave synthesizer for performing a wide range of organic and inorganic synthetic chemistry. The system features a best-in-class 300 mL single-mode microwave cavity, allowing for extremely flexible reaction vessel sizes, in both pressurized and open vessel modes. Read More >> |
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The Carousel 6 Plus offers parallel chemistry in the most universally accepted chemistry reaction vessel, the round bottom flask. The Carousel allows performing chemical reactions in various conditions, including an inert atmosphere; low/high temperatures; reflux; Dean & Stark; Tornado System for a powerful stirring of viscous samples as well as Breeze or Storm for controlled heating and cooling. Read More >> |
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Peptide Chemistry |
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Liberty Blue™ |
The Liberty Blue™ is an Automated Microwave Peptide Synthesizer. It features a 4-minute cycle time along with a 90% solvent reduction based on High-Efficiency Solid Phase Peptide Synthesis (HE-SPPS). This system uses microwave energy technology to provide a high-quality peptide. The Liberty Blue features the latest in engineering for fluidic deliveries, true internal temperature feedback control, and software control. Read More >> |
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Analysis and Purification |
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Thermo Scientific UltiMate 3000 HPLC system |
Thermo Scientific UltiMate 3000 rapid HPLC separation system combines unique hardware features and the ability to use small particle columns for fast separations with excellent resolution. Read More >> |
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UltiMate™ 3000 Semi-Preparative System |
The UltiMate™ 3000 Semi-Preparative System purifies compounds from microgram to lower-milligram quantities with accurate gradients and flexible flow rates. The system tolerates robust, safe, and high-performance purifications. The semi-preparative autosampler delivers milliliter injection volumes while minimizing backpressure contributions to support high flow rates at low backpressures. Read More >> |
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Auto Purification System of Waters |
The Waters AutoPurification HPLC/MS Systems provides scalable prep configurations, whether mass- or UV-directed. The system provides flexibility in using high-throughput parallel runs for selective mass-directed fraction collection from hundreds of samples, around the clock with unprecedented versatility and consistency. The system includes, inter-alia a 2767 Sample Manager; 2545 Binary Gradient Module; System Fluidics Organizer; 2998 Photodiode Array Detector; 2424 Evaporative Light Scattering Detector; SQ Detector 2 and MassLynx Software with the FractionLynx Application Manager. Read more >> |
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Biotage Isolera Systems |
Isolera™ Prime is a value-based system that recommends appropriate cartridges and calculates the best solvent conditions and gradients for purifications. The system includes solvent pumps and an automated fraction collector. Solvent use is minimized and advanced compound detection ensures that the purified compound is delivered at the end of the run. Isolera™ Prime performs at flow rates up to 100 ml/min with a pressure range of up to 145 psi (10 bars). The built-in UV detector (a choice of dual-wavelength or fixed options exists) detects aromatic and conjugated organic compounds and can trigger fractionation using threshold, slope, or volume parameters. Read more >> |
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Work-up |
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Biotage® VacMaster™ 10 |
Biotage® VacMaster™ Sample Processing Manifolds are used to process the complete range of ISOLUTE work-up columns. The manifold is used for Catch & Release and scavenging SPE, filtration, and off-line sample loading before flash chromatography. The Biotage® VacMaster™ is used, among other things, with cartridges such as the sodium sulfate drying cartridge; SCX-2 (for removing bases); PE-AX (for removing acids); PE-AX/SCX2 dual functional cartridge; metal scavenging cartridges; various phase separators, and more. Read more >> | ||
Evaporation & Concentration |
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Exchangeable block standard 15ml/50ml centrifugal tube sample concentrator |
Exchangeable block standard 15ml/50ml centrifugal tube sample concentrator. The nitrogen sample concentrator is mainly used for concentration or sample preparation in batches. Applications include drug screening, hormone analysis, and sample preparation for liquid chromatography and mass spectrometry. It works by blowing nitrogen over the surface of a heated sample to accelerate evaporation and separate the solvent without introducing oxygen. Unlike rotary evaporation instruments, the nitrogen sample concentrator can efficiently concentrate dozens of samples simultaneously. Read more >> |
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Rotavapor® R-300 |
Convenient and efficient, the R-300 rotary evaporator meets the highest expectations in convenience and versatility. Its modular design allows for optimal temperature setting, preferred immersion angle, and rotation speed, as well as the selection of the preferred evaporating flask size and thickness. Read more >> |
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Alpha 1-2 LDplus freezer dryer |
Compact, general-purpose tabletop unit for effective lyophilization of specimens in your everyday lab activities. The system allows you to choose from a wide range of configurations to adapt the freeze dryer optimally to your specific needs. It has a condenser temperature of -85 °C for specimens containing solvents or those with low eutectic points. |
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Biotage® V-10 Touch |
Biotage® V-10 Touch rapidly dries samples dissolved in both aqueous and organic solvents. It easily evaporates HPLC fractions from purification and high boiling point solvents from synthesis and features a novel dry-down onto silica technique for easier dry load capabilities before purification. Read more >> |