Chemistry Services
Medicinal Chemistry
- Rational design of new chemical entities based on ADME and drug-like properties
- Hit identification using dedicated software and medicinal chemistry knowledge
- NCE design
- NCE synthesis
- Structure-Activity Relationship, Hit to Lead
- Structure-Property Relationship
- Custom drug-like libraries
- Drug likeness analysis and prioritization
- Prediction of ADME properties
- Solubility studies
- Kinetic solubility
- Thermodynamic solubility
- LogD determination (shake-flask method)
- LogP determination (shake-flask method)
- Chemical stability
- Permeability (PAMPA)
- MDCK - MDR1 Transporter (PreadyPortTM kit)
- Metabolism studies
- Metabolite prediction and assessment by a dedicated software and medicinal chemistry knowledge
- Metabolite synthesis in a mg scale
- Metabolic Stability (Microsomes or S9 Fraction)
- Hepatocytes stability
- Plasma stability
- Plasma Protein Binding
- Blood-Brain Barrier penetration
- LogBBB prediction using dedicated software
- LogBBB prediction using dedicated software
Chemical Synthesis
- Synthetic route scouting
- Scouting for new, better, alternate routes toward the synthesis of a small molecules
- Organic synthesis using state of the art infrastructure
- Multistep synthesis of novel compounds, design and optimization
- Custom chemical libraries
- Synthesis and identification of impurities
- Synthesis and identification of metabolites
- Feasibility studies
- Assessment of a new and patentable chemical steps or entire route of synthesis
- Scale up studies (to grams scale)
- Synthesis process optimization and parametrization
- Development of an efficient, green, cost, and time-effective patentable synthetic process
- Compound identity and purity confirmation
- Literature survey
Peptide Synthesis
- Linear peptides
- Cyclic and branched peptides
- Fluorescent labeled peptides
- Amino acids- Activity Relationship Study
- Peptide stability studies
- Cupped peptides
- Assimilation of unnatural amino acids
- Stapled and stitched peptides
- Custom peptide design (considering permeability and plasma stability requirements)
Natural products
- Extraction
- Biomass: Solvent extraction (shaking/sonication bath), microwave assisted extraction and reflux extraction
- Microbial secreted metabolites: Extraction of secreted metabolites from culture media using absorbent polymers
- Isolation
- Separation based on the molecular size
- Separation based on adsorption properties (Normal phase/reversed phase) from gram to mg scale
- Mass directed purification
- Structure elucidation
- High Resolution mass spectrometry
- 1D and 2D NMR studies
- Spectroscopic data (UV and IR)
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