Chemistry Services

Medicinal Chemistry

• Rational design of new chemical entities based on ADME and drug-like properties
  • Hit identification using dedicated software and medicinal chemistry knowledge
  • NCE design
  • NCE synthesis
  • Structure-Activity Relationship, Hit to Lead
  • Structure-Property Relationship
  • Custom drug-like libraries
  • Drug likeness analysis and prioritization
  • Prediction of ADME properties
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• Solubility studies
  • Kinetic solubility
  • Thermodynamic solubility
     

• ​LogD determination (shake-flask method)
• LogP determination (shake-flask method)
• Chemical stability
• Permeability (PAMPA)
• MDCK - MDR1 Transporter (PreadyPortTM kit)
• Metabolism studies
  • Metabolite prediction and assessment by a dedicated software and medicinal chemistry knowledge
  • Metabolite synthesis in a mg scale
  • Metabolic Stability (Microsomes or S9 Fraction)
  • Hepatocytes stability
  • Plasma stability
  • Plasma Protein Binding
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• Blood-Brain Barrier penetration
  • ​LogBBB prediction using dedicated software
     

Chemical Synthesis

• Synthetic route scouting
  • Scouting for new, better, alternate routes toward the synthesis of a small molecules
• Organic synthesis using state of the art infrastructure
  • Multistep synthesis of novel compounds, design and optimization
  • Custom chemical libraries
  • Synthesis and identification of impurities
  • Synthesis and identification of metabolites
• Feasibility studies
  • Assessment of a new and patentable chemical steps or entire route of synthesis
• Scale up studies (to grams scale)
• Synthesis process optimization and parametrization
  • Development of an efficient, green, cost, and time-effective patentable synthetic process
• Compound identity and purity confirmation
• Literature survey

Peptide Synthesis

• Linear peptides
• Cyclic and branched peptides
• Fluorescent labeled peptides
• Amino acids- Activity Relationship Study
• Peptide stability studies
• Cupped peptides
• Assimilation of unnatural amino acids
• Stapled and stitched peptides
• Custom peptide design (considering permeability and plasma stability requirements)

Natural products

• Extraction
  • Biomass: Solvent extraction (shaking/sonication bath), microwave assisted extraction and reflux extraction
  • Microbial secreted metabolites: Extraction of secreted metabolites from culture media using absorbent polymers
• Isolation
  • Separation based on the molecular size
  • Separation based on adsorption properties (Normal phase/reversed phase) from gram to mg scale
  • Mass directed purification
• Structure elucidation
  • High Resolution mass spectrometry
  • 1D and 2D NMR studies           
  • Spectroscopic data (UV and IR)