Chemistry Services
- Rational design of new chemical entities based on ADME and drug-like properties
- Hit identification using dedicated software and medicinal chemistry knowledge
- NCE design
- NCE synthesis
- Structure-Activity Relationship, Hit to Lead
- Structure-Property Relationship
- Custom drug-like libraries
- Drug likeness analysis and prioritization
- Prediction of ADME properties
- Solubility studies
- Kinetic solubility
- Thermodynamic solubility
- LogD determination (shake-flask method)
- LogP determination (shake-flask method)
- Chemical stability
- Permeability (PAMPA)
- MDCK - MDR1 Transporter (PreadyPortTM kit)
- Metabolism studies
- Metabolite prediction and assessment by a dedicated software and medicinal chemistry knowledge
- Metabolite synthesis in a mg scale
- Metabolic Stability (Microsomes or S9 Fraction)
- Hepatocytes stability
- Plasma stability
- Plasma Protein Binding
- Blood-Brain Barrier penetration
- LogBBB prediction using dedicated software
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Welcome to the BCDD
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