Chemistry Services

Chemistry Services
Chemistry Services at the BCDD

Medicinal Chemistry

  • Rational design of new chemical entities based on ADME and drug-like properties
    • Hit identification using dedicated software and medicinal chemistry knowledge
    • NCE design
    • NCE synthesis
    • Structure-Activity Relationship, Hit to Lead
    • Structure-Property Relationship
    • Custom drug-like libraries
    • Drug likeness analysis and prioritization
    • Prediction of ADME properties
  • Solubility studies
    • Kinetic solubility
    • Thermodynamic solubility
       
  • ​LogD determination (shake-flask method)
  • LogP determination (shake-flask method)
  • Chemical stability
  • Permeability (PAMPA)
  • MDCK - MDR1 Transporter (PreadyPortTM kit)
  • Metabolism studies
    • Metabolite prediction and assessment by a dedicated software and medicinal chemistry knowledge
    • Metabolite synthesis in a mg scale
    • Metabolic Stability (Microsomes or S9 Fraction)
    • Hepatocytes stability
    • Plasma stability
    • Plasma Protein Binding
  • Blood-Brain Barrier penetration
    • ​LogBBB prediction using dedicated software
       

Chemical Synthesis

  • Synthetic route scouting
    • Scouting for new, better, alternate routes toward the synthesis of a small molecules
  • Organic synthesis using state of the art infrastructure
    • Multistep synthesis of novel compounds, design and optimization
    • Custom chemical libraries
    • Synthesis and identification of impurities
    • Synthesis and identification of metabolites
  • Feasibility studies
    • Assessment of a new and patentable chemical steps or entire route of synthesis
  • Scale up studies (to grams scale)
  • Synthesis process optimization and parametrization
    • Development of an efficient, green, cost, and time-effective patentable synthetic process
  • Compound identity and purity confirmation
  • Literature survey

 

Peptide Synthesis

  • Linear peptides
  • Cyclic and branched peptides
  • Fluorescent labeled peptides
  • Amino acids- Activity Relationship Study
  • Peptide stability studies
  • Cupped peptides
  • Assimilation of unnatural amino acids
  • Stapled and stitched peptides
  • Custom peptide design (considering permeability and plasma stability requirements)

 

Natural products

  • Extraction
    • Biomass: Solvent extraction (shaking/sonication bath), microwave assisted extraction and reflux extraction
    • Microbial secreted metabolites: Extraction of secreted metabolites from culture media using absorbent polymers
  • Isolation
    • Separation based on the molecular size
    • Separation based on adsorption properties (Normal phase/reversed phase) from gram to mg scale
    • Mass directed purification
  • Structure elucidation
    • High Resolution mass spectrometry
    • 1D and 2D NMR studies           
    • Spectroscopic data (UV and IR)
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