Chemistry Services

Chemistry Services
Chemistry Services at the BCDD

Hit Identification and Design

  • Hit identification: integrating software and medicinal chemistry insights
  • NCE (new chemical entity) design strategies
  • NCE synthesis techniques

 

Structure-Activity and Structure-Property Relationships

  • From hit to lead: structure-activity relationship (SAR)
  • Understanding structure-property relationships (SPR)

 

Custom Libraries and Drug Likeness

  • Development of custom drug-like libraries
  • Drug likeness analysis and prioritization
  • ADME property prediction for drug candidates

 

Solubility Studies

  • Solubility studies for drug development
  • Kinetic solubility assessment
  • Thermodynamic solubility evaluation

 

LogD and LogP Determination

  • LogD determination via shake-flask method
  • LogP determination via shake-flask method

 

Stability Studies

  • Chemical stability analysis
  • Permeability testing (PAMPA)
  • MDCK - MDR1 transporter studies (PreadyPort™ kit)

 

Metabolism and Metabolite Studies

  • Comprehensive metabolism studies
  • Metabolite prediction and assessment using software and medicinal chemistry
  • Metabolite synthesis on mg scale
  • Metabolic stability in microsomes or S9 fraction
  • Hepatocyte stability studies
  • Plasma stability testing
  • Plasma protein binding analysis

 

Blood-Brain Barrier and LogBBB Prediction

  • Blood-brain barrier penetration studies
  • LogBBB prediction using dedicated software
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