Chemistry Services

Hit Identification and Design

• Hit identification: integrating software and medicinal chemistry insights
• NCE (new chemical entity) design strategies
• NCE synthesis techniques

Structure-Activity and Structure-Property Relationships

• From hit to lead: structure-activity relationship (SAR)
• Understanding structure-property relationships (SPR)

Custom Libraries and Drug Likeness

• Development of custom drug-like libraries
• Drug likeness analysis and prioritization
• ADME property prediction for drug candidates

Solubility Studies

• Solubility studies for drug development
• Kinetic solubility assessment
• Thermodynamic solubility evaluation

LogD and LogP Determination

• LogD determination via shake-flask method
• LogP determination via shake-flask method

Stability Studies

• Chemical stability analysis
• Permeability testing (PAMPA)
• MDCK - MDR1 transporter studies (PreadyPort™ kit)

Metabolism and Metabolite Studies

• Comprehensive metabolism studies
• Metabolite prediction and assessment using software and medicinal chemistry
• Metabolite synthesis on mg scale
• Metabolic stability in microsomes or S9 fraction
• Hepatocyte stability studies
• Plasma stability testing
• Plasma protein binding analysis

Blood-Brain Barrier and LogBBB Prediction

• Blood-brain barrier penetration studies
• LogBBB prediction using dedicated software